לוח משרות דרושים מדעי החיים, טבע וחקלאות בחולון

Required Analyst
Job Description:
A clinical-stage drug discovery and development company in the field of cancer immunotherapy. In line with our business model to enter into collaborations for their internally discovered, novel therapeutic candidates at various stages in research and development, the company is seeking an Analyst in support of its partnering efforts.
Reporting to the SVP Strategic Collaborations, the Analyst will lead competitive intelligence (CI) and business analysis activities to support BD and corporate objectives. She/he will be responsible for supporting aspects of competitive analysis and other activities relating to partnering efforts.
Constantly monitor the pharma and biotech space and gather competitive intelligence from various sources including company portfolios, preclinical and clinical activities, scientific data, partnerships, deal structures and terms, and other relevant intelligence
Perform analyses and provide insights into competitive landscapes, industry trends and perspectives, market developments, product developments and positioning, as well as other intelligence in support of our BD&L and R&D efforts
Provide regular updates to our management and functions
Develop Target Product Profiles for our development candidates in close collaboration with R&D teams, and build forecast models based on epidemiological data as well as customer/patient segmentation, pricing and access assumptions
Identify potential collaboration partners for various pipeline opportunities
Work closely with our R&D community and drive the preparation of materials surrounding the companys pipeline programs for internal presentation to management and also to potential partners
Contribute to the creation of valuation models and financial valuation of business development opportunities against partnering scenarios.

Required Research Lab Technician
Job Description:
The research technician will support ex-vivo and in-vitro experiments, as a part of the functional validation of immunomodulatory molecules discovered by us.
The research work under the supervision of scientists will include expression studies in human and mouse tumor-infiltrating immune cells, and functional immune assays for elucidation of mode of action.
Assist in processing and characterizing human and mouse tumor tissues
Perform immune cell isolation from human and mouse blood
Support tissue culture experiments (flow cytometry, cytokine analysis)
Assist in genotyping of mouse strains
Support with laboratory maintenance duties e.g., handling routine tasks such as preparing stocks of common lab reagents, maintaining lab databases, etc.
Temporary position until the end of the year 10 hours a week.

Required Translational and Bioanalytical Research Associate
Job Description
The Translational and bioanalytical research associate will oversee the Companys translational and bioanalytical activities that are essential for drug development activities, preclinical and clinical. This typically includes bioanalytical methods development and use for pharmacokinetic and immunogenicity evaluation, as well as methods needed for pharmacodynamic exploration, such as cytokines, receptor occupancy, immunophenotyping, and a support for drug manufacturing development activities (CMC). The candidate will ensure the methods are developed, validated, and used with the highest degree of quality and compliance with international regulations.
The candidate will work with cross functional teams across the organization (preclinical biomarker/translational research, clinical development, clinical operations, CMC, regulatory, clinical data management) to ensure the successful PK and PD sample analysis for investigational drugs in our pipeline.
Be responsible for the bioanalytical methods required for our various therapeutic programs at preclinical and clinical development stage. This includes assay set-up, optimization, validation, execution, tracking of program and study timelines, review of bioanalytical protocols and reports
Propose format and strategy for pharmacokinetic and pharmacodynamic assays, immunogenicity assays such as ADA and NAb assay, flow cytometry immunophenotyping panels, Receptor occupancy assays, etc.)
Support the selection and the oversight of external advisors/Contract Research Organizations, including participating to quality assurance audits
Monitor internal and external work on bioanalytical methods
Collaborate with scientific colleagues in the R&D units from discovery to clinical teams
Maintain an up-to-date understanding of the state-of-the-Art literature, requirements, and regulatory guidelines for bioanalytical methods used in drug development
Present written and oral reports to preclinical units and management
Contribute to Project Management activities such as definition of activities, timelines, and costs/budgets
Contribute to the data analysis and summaries of results derived from pre-clinical and clinical sample analysis
Contribute to preclinical and clinical documentation definition and writing for the sections related to bioanalytical methods.

Required Bioinformatics Scientist / Senior Bioinformatics Scientist
Job Description:
Our extraordinary multidisciplinary team is one of its greatest assets. Our employees, coming from different backgrounds with diverse ways of thinking, work together in an atmosphere that cultivates excellence, creativity and openness. The cooperation of people from various disciplines involving different areas of expertise is fundamental to our ability to establish unique predictive drug discovery solutions, as well as to discover and develop novel therapeutic proteins and drug targets. This merging of talent from various disciplines continues to serve as a key growth driver and enables us to fulfill our mission and business goals. We are expanding our bioinformatics and data engineering team under the Computational Discovery unit and seek a Bioinformatics Scientist / Senior Bioinformatics Scientist to drive hands-on data analysis and algorithms development towards novel targets discovery and enhancement of our cloud-based computational biology platform. The Bioinformatics Scientist / Senior Bioinformatics Scientist will play a key role in the development of our Computational Discovery analytics platform towards the in-silico identification of drug targets and novel biomarkers in immune-oncology (IO). The Bioinformatics Scientist / Senior Bioinformatics scientist will report to the Head of Computational Discovery.
Conduct end-to-end computational analyses of single cell and spatial transcriptomics data
Contribute to establishment and maintenance of single-cell and additional bioinformatics processing pipelines
Implement tools for cross-dataset and multi-omics data harmonization, integration, and visualization
Develop and implement innovative computational biology algorithms and data science approaches towards identification and in-silico validation of novel immuno-oncology targets and biomarkers
Advance analytics support for in-vitro and in-vivo validation of drug targets, mechanism-of-action (MOA) analysis, patients stratification and biomarkers discovery
Work closely and routinely with computational scientists, biologists and immunologists
Present, visualize and communicate the analytics results and scientific insights to internal and external collaborators.

Required Senior Project Manager
Job Description:
Reporting to the Senior Director, R&D Project Management, this position is responsible for managing project team interactions to ensure the successful and timely achievement of decision points from the research and drug discovery phase to clinical phase. This position will work closely with different units including the Research and Drug Discovery team, who validates our novel drug targets for the development of therapeutic mAbs for cancer treatment and the Clinical team, who is responsible for all clinical studies aspects. By employing project strategy and tools, this position assists the project core teams to deliver on project and corporate objectives.
This position supports the Senior Director, R&D Project Management in overall responsibility for managing our projects, while remaining aligned with the Companys strategy and goals.
Work closely and routinely with project related units as Computational Discovery, Research and Drug Discovery, Clinical, Finance, IP, Preclinical, CMC and BD
For each project, determine and define the project overall scope, objectives, and deliverables together with project core team members
For each project, develop with the project team and manage a detailed project work plan including detailed timelines, budget, resources, risk/opportunities, projects decision points and critical path, monitor progress and adjust, as needed
Is accountable for achieving the agreed milestones at the project level, by meeting the agreed company and regulatory requirements according to time, quality/scope and budget constraints
Actively facilitate recurrent project team meetings to track project status, including the preparation of meeting agendas, minutes, and follow-up on action items. Ensure project documentation is being organized and stored
Utilize industry best practices, techniques, and oversight compliance with all relevant guidelines, legislation, and SOPs throughout the entire project execution
Assist in generating monthly reports/dashboards on project progress to various stakeholders and governance bodies
Measure project performance to identify areas for improvement; Identify, recommend, and implement opportunities for streamlining programs.